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  • Title: Digoxin acute intoxication: evaluation of the efficiency of charcoal hemoperfusion.
    Author: Clerckx-Braun F, Kadima N, Lesne M, Mahieu P, Vandenbroucke JM.
    Journal: Clin Toxicol; 1979; 15(4):437-46. PubMed ID: 540492.
    Abstract:
    Since there is no widely used method of reducing the severity of massive digoxin intoxication, the capacity of hemoperfusion with coated, activated charcoal to remove digoxin was evaluated in a case of suicidal digoxin ingestion (25 mg). Seven hours after ingestion the digoxin plasma level was equal to 8.9 ng/ml. This was decreased to 4.5 ng/ml after 6 hr hemoperfusion. The amount of digoxin adsorbed by the column represents 4.8% of the absorbed dose. At a blood flow rate of 170 ml/min, the mean digoxin clearance by hemoperfusion was 44.5 +/- 26.9 ml/min. From these results we conclude that charcoal hemoperfusion in acute digoxin intoxication is of little value.
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