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  • Title: Induction of rabbit antibody with molecular uniformity after immunization with group C streptococci.
    Author: Eichmann K, Lackland H, Hood L, Krause RM.
    Journal: J Exp Med; 1970 Jan 01; 131(1):207-21. PubMed ID: 5409946.
    Abstract:
    Antibodies with uniform properties may occur in rabbits after immunization with Group C streptococci. These precipitating antibodies possess specificity for the group-specific carbohydrate. Not uncommonly, their concentration is between 20 and 40 mg/ml of antiserum. Evidence for molecular uniformity in the case of one of these antibodies, described in detail here, includes: individual antigenic specificity; monodisperse distribution of the light chains by alkaline urea polyacrylamide disc electrophoresis; and a single amino acid in each of the first three N-terminal positions of the light chains. When the amino acid sequence of rabbit antibody b+ light chains (kappa type) are aligned against their human kappa counterparts, a definite homology is observed between the N-terminus of the human and the rabbit variable region.
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