These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Bladder cancer induction by aromatic amines: role of N-hydroxy metabolites.
    Author: Radomski JL, Brill E.
    Journal: Science; 1970 Feb 13; 167(3920):992-3. PubMed ID: 5411180.
    Abstract:
    Repeated installation of N-hydroxy-2 naphthylamine into dog bladders produced tumors of this organ. There is a correlation of degree of carcinogenicity of 1-naphthylamine, 2-naphthylamine, and 4-aminobiphenyl with both methemoglobin production in the blood and concentration of N-oxidation products in the urine. Thus, N-hydroxylation appears to be the key to bladder cancer production by aromatic amines.
    [Abstract] [Full Text] [Related] [New Search]