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  • Title: Localization of the acetylcholine receptors in denervated muscles of rats.
    Author: Lorković H, Hooker WM, Tomanek RJ.
    Journal: Arch Int Physiol Biochim; 1975 Aug; 83(3):493-504. PubMed ID: 54129.
    Abstract:
    ACh contractures of denervated lumbricalis muscles of rats were washed in Tris-methanesulfonate solutions and in sucrose solutions. The peak tension was diminished by about 80% following a 30 min exposure to solutions containing 400-600 mM glycerol when Tris solutions were used in the testing period, and by about 50% when sucrose solutions were used. The amplitude of the membrane potential changes provoked by ACh was decreased by about 36% following the glycerol treatment. The treatment had no effect on the ACh-induced 45Ca uptake of muscles. Electron microscopy of the glycerol-treated muscles showed widespread vacuolization apparently originating from swelling and disruption of the T system. It was concluded that ACh receptors which arise in the muscle membrane following nerve section are distributed in the external surface membrane and in the membranes of the T system.
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