These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Determination of bromhexine as its trifluoroacetyl derivative by gas-liquid chromatography with electron-capture detection.
    Author: De Leenheer AP, Vandecasteele-Thienpont LM.
    Journal: J Chromatogr; 1979 Jul 13; 175(2):301-6. PubMed ID: 541435.
    Abstract:
    A specific gas-liquid chromatographic method with electron-capture detection is described for the determination of bromhexine at the nanogram level. Structurally analogous internal standards were synthesized and their suitability was investigated, based on their chromatographic properties on different stationary liquid phases. The electron-capture activity of the compounds is increased by trifluoroacetylation. Reaction conditions for this derivatization were studied. Calibration graphs in the range 0-57 ng (in a total of 100 microliters of reaction mixture) showed good linearity.
    [Abstract] [Full Text] [Related] [New Search]