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  • Title: Characterization of the structure of a 4-methyl-delta 8,24-cholestadien-3 beta-ol isolated from rat skin.
    Author: Sanghvi A.
    Journal: J Lipid Res; 1970 Mar; 11(2):124-30. PubMed ID: 5418475.
    Abstract:
    A new sterol has been isolated from the skin of rats treated with triparanol. Its chromatographic behavior on silicic acid-Celite columns and in gas-liquid chromatographic systems indicated it to be a 4-methyl-Delta(8,24)-cholestadien-3beta-ol. The specific rotation, the delayed color reaction with Liebermann-Burchard reagent, and the nuclear magnetic resonance (NMR) data support the Delta(8(9))-unsaturation. Previous workers have shown that triparanol treatment results in an accumulation of Delta(24)-unsaturated sterols in animal tissues. Consonant with this observation, the infrared, NMR, and mass spectrometric data confirm the presence of a C-24(25) unsaturated side chain in this sterol.
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