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  • Title: Two molecular forms of thymidine kinase in the cytosol of regenerating rat liver.
    Author: Nawata H, Kamiya T.
    Journal: J Biochem; 1975 Dec; 78(6):1215-24. PubMed ID: 5419.
    Abstract:
    Two forms (Peak A and Peak B) of thymidine kinase [EC 2.7.1.75] from regenerating rat liver cytosol were resolved and partially purified by Deae-cellulose chromatography. Both fractions were identical with respect to their substrate requirement, pH optima, metal requirements, and molecular weight, as judged by their sedimentation in sucrose density gradient centrifugation. Peak B differed from Peak A in heat sensitivity, inhibition by dCTP and Km for thymidine and ATP. Peak B enzyme was the only enzyme found in normal adult liver and Peak A enzyme was the form increasing predominantly in regenerating liver.
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