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  • Title: Hundred day leukemia: preferential induction in rat by pulse-doses of 7,8,12-trimethylbenz(a)anthracene.
    Author: Huggins C, Grand L, Oka H.
    Journal: J Exp Med; 1970 Feb; 131(2):321-30. PubMed ID: 5419851.
    Abstract:
    A series of pulse-doses of 7, 8, 12-trimethylbenz(a)anthracene-induced leukemia rapidly and consistently in very high yield in rats of Long-Evans (L-E) strain. The predominant type was a diffuse hepatic leukemia of erythroblastic stem cells. Progressive hypothermia and a decline in pituitary function are newly recognized signs of advanced leukemia in rat.
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