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  • Title: [E-vitamin activity of vitamin E derivatives with experimental encephalomalacia in chicks].
    Author: Kovalenko VN, Donchenko GV, Makovetskiĭ VP, Svishchuk AA.
    Journal: Ukr Biokhim Zh (1978); 1979; 51(6):665-8. PubMed ID: 543031.
    Abstract:
    When adding pharmacopoeian alpha-tocopherylacetate, short-chain alpha-tocopherylacetate, alpha-tocopherylquinine, short-chain alpha-tocopherylquinone and alpha-tocopheronolactone to E-avitaminotic rations pharmacopoeian alpha-tocopherylacetate and alpha-tocopheronolactone manifest the highest E-vitamin activity in preventing encephalomalacia in chickens. The action of alpha-tocopheronolactone is not directly associated with changes in the content of vitamin E and ubiquinone in the brain and liver tissues. All the studied derivatives are effective in increasing resistance of erythrocytes to osmotic hemolysis. The data obtained evidence for a nonspecific function of vitamin E in preventing alimentary encephalomalacia in chickens as well as for the absence of disturbances in ubiquinone metabolism under conditions of the E-hypovitaminosis experimental model.
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