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  • Title: [Kinetic studies of the technical phosphate of Pharmachem tylosin in chickens and pigs].
    Author: Donev B.
    Journal: Vet Med Nauki; 1979; 16(8):85-94. PubMed ID: 543107.
    Abstract:
    Studies on the pharmaco-kinetics of the technical tylosine phosphate (TTP) with an activity of 50 UI/mg were carried out using chickens and pigs. It was established that the tylosine phosphate contained in TTP is resorbed in the alimentary canal of the chickens and produces the needed bacteriological concentrations in the blood both following single intraingluvial application (in doses of 1 and 2 g/kg b.w.) and after application via fodder (in doses of 10 and 20 g/kg b.w.). Absorption of the preparation by the digestive tract of pigs following compulsory application is satisfactory, but it is very slight and uneven in case of application through the food ration. Therefore, the use of TTP in this way should be limited in swine only and exclusively for therapy or prophylaxis of intestinal infections (dysentery, necrotic enteritis, etc). Following resorption TTP penetrates to a varying extent in the individual organs, tissues and fluids of chicken and pig organisms and remains there for a long period of time. It is eliminated mainly through the gall bladder secretion and by the urine, as well as by the eggs (of layers). In order not to allow residual quantities of the antibiotic in the products obtained from treated mammals and birds TTP application must cease 4--5 days before decapitation. The use of preparation for hens of commodity farms is not appropriate.
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