These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Menstrual dysfunction following use of oral contraceptives.
    Author: Homesley HD, Goss DA.
    Journal: Obstet Gynecol; 1970 May; 35(5):734-9. PubMed ID: 5441266.
    Abstract:
    An evaluation of 13 patients with menstrual dysfunction following discontinuation of oral contraceptives is presented. All had normal ovulatory cycles of 26-34 days before beginning oral contraceptive medication. The duration of therapy was 3-42 months with 14 months the mean. Relationship between occurrence of menstrual dysfunction and duration of therapy or type of agent administered was not noted. 9 were classified as amenorrheic (6 months or more of secondary amenorrhea) and their condition lasted from 6 to 36 months. Cervical mucus from 6 demonstrated a 3 to 4+ fern phenomena, indicating significant endogenous estrogen production. Gynecologic endocrine status was evaluated by basal body temperature, endometrial biopsy, and cervical mucus arborization. Total gonadotropins were measured in those demonstrating poor or absent fern phenomenon. Adrenal and thyroid functions were measured by 17-ketosteroid and 17-hydroxysteroid excretion and PBI respectively. Patients were screened for pituitary tumors by X-ray and visual examinations. Clomiphene (Clomid) was administered to 6 patients in 5 day courses of 50 or 100 mg per day. Of these 4 responded with ovulatory cycles. One became pregnant. 2 patients not responding to several such courses, were given human menopausal gonadotropin (HMG Pregova) in doses of 140 I.U. a day until cervical mucus demonstrated 4+ fern phenomenon. Human chorionic gonadotropin (HCG) was then given in a single dose of 5000 I.U. One responded to this treatment and became pregnant. 3 were not treated because they did not desire conception or ovulation induction. The 4 patients who were amenorrheic for less than 6 months were considered oligomenorrheic. 2 responded to clomiphene but the pattern of prolonged follicular phase has recurred in both. Their menstrual dysfunction is thought to be due to delayed recovery from suppression of some hypothalamic-pituitary mechanisms involved in normal gonadotropin regulation. Gonadtropin therapy is the only effective method of ovulation induction in those patients who fail to respond to clomiphene.
    [Abstract] [Full Text] [Related] [New Search]