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  • Title: The effect of acetyl strophanthidin on the hearts of normal dogs.
    Author: Hayes AH, McShane WP, Sidell FR.
    Journal: Br J Pharmacol; 1970 May; 38(3):616-9. PubMed ID: 5441414.
    Abstract:
    1. The ED50 of acetyl strophanthidin for producing ventricular arrhythmias in normal dogs was 54.5 mug/kg intravenously.2. Doses up to and including those which caused ventricular tachycardia did not produce either atrial arrhythmias or significant aberration of A-V conduction.3. Although the classic digitalis-induced rate and e.c.g. waveform changes may appear after administration of acetyl strophanthidin, their presence or absence have no value in predicting the subsequent development of ventricular arrhythmias.
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