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  • Title: Metabolite of (-)-trans-delta 8-tetrahydrocannabinol: identification and synthesis.
    Author: Foltz RL, Fentiman AF, Leighty FG, Walter JL, Drewes HR, Schwartz WE, Page TF, Truitt EB.
    Journal: Science; 1970 May 15; 168(3933):844-5. PubMed ID: 5444059.
    Abstract:
    The major metabolite of (-)-trans-Delta(8)-tetrahydrocannabinol observed in vivo and formed by hepatic microsomes in vitro is 11-hydroxy-trans-Delta(8)-tetrahydrocannabinol. The metabolite was identified spectroscopically and was synthesized from trans-Delta(8)-tetrahydrocannabinol. In tests with rats, the metabolite produced behavioral effects similar to those imparted by Delta(8)- and Delta(9)-tetrahydrocannabinol.
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