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  • Title: Norepinephrine turnover and metabolism in rat brain after long-term administration of imipramine.
    Author: Schildkraut JJ, Winokur A, Applegate CW.
    Journal: Science; 1970 May 15; 168(3933):867-9. PubMed ID: 5444064.
    Abstract:
    The rate of disappearance of intracisternally administered tritiated norepinephrine from rat brain is decreased after a single dose of the tricyclic antidepressant imipramine. During long-term administration of imipramine, however, the rate of disappearance of tritiated norepinephrine from brain gradually increases, and there is a concurrent decrease in the content of endogenous norepinephrine in brain. These findings may help to explain why antidepressant effects are observed clinically only after long-termn treatment with imipramine.
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