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  • Title: Occurrence of epithelial atypia in 51 Indian villagers with oral submucous fibrosis.
    Author: Pindborg JJ, Mehta FS, Daftary DK.
    Journal: Br J Cancer; 1970 Jun; 24(2):253-7. PubMed ID: 5451568.
    Abstract:
    Fifty-three biopsies from the oral mucosa in 51 Indian villagers with oral submucous fibrosis have been studied for epithelial changes. A marked atrophy of the epithelium was found in 71.7%; the atrophic epithelium showed no rete ridges. The normally unkeratinized buccal mucosa revealed either ortho- or parakeratosis or hyperortho- or hyperparakeratosis in 48.0%. In one patient the histologic examination disclosed a squamous cell carcinoma. In 22.6% an epithelial atypia was found. The histologic features in these atypias are compared with those seen in leukoplakias from the same survey. The possible precancerous nature of submucous fibrosis is discussed.
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