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  • Title: IgA nephropathy (Clinical, pathological and immunological findings).
    Author: Moriconi L, Paleologo G, Bedini L, Cioni L.
    Journal: Ric Clin Lab; 1979; 9(4):369-77. PubMed ID: 545645.
    Abstract:
    Seventy-five biopsy samples from patients with chronic renal disorders were examined by the usual techniques of light microscopy and immunofluorescence; in fifteen patients IgA nephropathy was found. These patients were young adults; the onset of the disease was characterized by macrohematuria, and recurrent episodes of hematuria were observed. Histological examination revealed proliferative endothelio-mesangial glomerulonephritis at various stages of development with focal or diffuse patterns; immunofluorescence revealed constant and intense positive reactions for IgA mainly in association with C3. It is assumed that there is a relationship connecting the more advanced histological changes, a more severe clinical course and the presence of IgM deposits.
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