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  • Title: [Medroxyprogesterone acetate in depot form for contraception].
    Author: Mark I.
    Journal: Ugeskr Laeger; 1979 Jul 16; 141(29):1965-8. PubMed ID: 545763.
    Abstract:
    On the basis of a series of foreign and Danish investigations, a review is presented of the employment of medroxyprogesterone acetate in depot form (Depo Provera) for contraception. It is emphasized that the method practically invariably involves disturbances in menstruation, most frequently in the form of amenorrhea but accasionally as metrorrhagia or frequent spotting. Patients can usually accept absence of menstruation provided they are informed about this side effect in advance. The effect of the preparation is primarily interpreted as gonadotropin inhibition with cessation of ovulation together with a more peripheral gestagenic effect on the endometrium and cervical mucosa. Thus spermatozoa have difficulty in penetrating the uterine cavity and nidation is prevented. The possibility of a diabetogenic effect is discussed but investigations hitherto have not been able to confirm this. Alterations in blood pressure or coagulation factors have not been demonstrated in any investigations. Investigations of vaginal smears have not revealed significant evidence of an increased incidence of abnormal cells or carcinoma in situ. The method is interpreted as a supplement to the existing forms of contraception and is particularly suitable in cases where combined preparations are contraindicated, where the IUD cannot be employed, or in clients who cannot use oral or other forms of contraception.
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