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  • Title: High-pressure liquid chromatography of drugs. II. An evaluation of a microparticulate cation-exchange column.
    Author: Twitchett PJ, Gorvin AE, Moffat AC.
    Journal: J Chromatogr; 1976 May 26; 120(2):359-68. PubMed ID: 5461.
    Abstract:
    A microparticulate cation-exchange column has been evaluated for the chromatography of thirty compounds selected as representative of a wide variety of drug substances. Although the column exhibited a strong partition effect besides the expected ion-exchange mechanism, the retention of drugs could be predictably influenced by variation of the eluent ionic strength and organic solvent content. For acidic drugs the column showed little selectivity (although a salting-out effect increased retention at high eluent ionic strengths), but for basic substances Partisil SCX may afford a useful separative medium offering reasonable chromatographic efficiency (HETP is approximately 0.1 mm). The column longevity, however, is at present questionable.
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