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  • Title: [Photoprotection by psoralen-UVA therapy: experimental and clinical results (author's transl)].
    Author: Gschnait F, Brenner W, Wolff K.
    Journal: Wien Klin Wochenschr; 1979 Dec 21; 91(24):812-7. PubMed ID: 547490.
    Abstract:
    Studies on minimum erythema doses, histological investigations and quantitative determination of DNA repair synthesis of epidermal cells revealed that a tan induced by the oral administration of 8-methoxy-psoralen (8-MOP) and subsequent UVA irradiation gives protection from the erythemogenic effects of sunlight, diminishes UVA-induced cellular injury in the epidermis and, possibly, also shields DNA from incident UV radiation. In a study of 14 patients with severe polymorphous light dermatosis the 8-MOP-UVA induced tan proved to be a clinically effective sunscreen. The uncontrolled use of this method for UV protection of normal individual is, however, not recommended.
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