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  • Title: Analytical study of the degradation of nucleohistone during calf thymus chromatin autolysis.
    Author: Combard A, Vendrely R.
    Journal: Biochem J; 1970 Aug; 118(5):875-81. PubMed ID: 5476730.
    Abstract:
    The mechanism of nucleohistone degradation in calf thymus chromatin during autolysis of the latter involves a release of lysine-rich histone fractions, followed by degradation of the thus-exposed DNA portions; the latter portions are richest in adenine-thymine sequences. After this degradation process, residual nucleohistone fragments of low molecular weight (10(5)) remain. Their chemical composition is special, in that the DNA contains a larger proportion of guanine-cytosine sequences than does the initial DNA and it is combined with arginine-rich histones.
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