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  • Title: An assessment of techniques suitable for the diagnosis of sickle-cell disease and haemoglobin C disease in cord blood samples.
    Author: Yaswon GI, Huntsman RG, Metters JS.
    Journal: J Clin Pathol; 1970 Sep; 23(6):533-7. PubMed ID: 5476880.
    Abstract:
    Agar gel, cellulose acetate, and starch gel electrophoresis are all capable of diagnosing sickle-cell anaemia, sickle-cell haemoglobin C disease, and haemoglobin C disease in cord blood samples. Of these three electrophoretic techniques, agar gel is the easiest to interpret.Paper electrophoresis can reliably and rapidly detect sickle haemoglobin and haemoglobin C in cord blood samples. Being incapable of differentiating foetal and normal adult haemoglobin, the value of paper electrophoresis is limited to an initial screening procedure.
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