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  • Title: Impaired lymphocyte stimulation by some streptococcal antigens in patients with recurrent aphthous stomatitis and rheumatic heart disease.
    Author: Francis TC, Oppenheim JJ.
    Journal: Clin Exp Immunol; 1970 Apr; 6(4):573-86. PubMed ID: 5477922.
    Abstract:
    The effects of pathogenic and non-pathogenic streptococci, streptococcal cell wall products, and phytohaemagglutinin on human peripheral leucocyte cultures from four groups were studied. These groups were: (1) normals, (2) patients with aphthous stomatitis, (3) patients with Behçet's and (4) patients with rheumatic heart disease. The degree of lymphocyte stimulation by these materials was measured by uptake of [3H]thymidine into DNA in vitro. In normals, patients with aphthous stomatitis, and Behçet's disease, the human pathogenic group A streptococci produced significantly greater stimulation of DNA synthesis than did the less pathogenic non-haemolytic streptococci. Lymphocytes from patients with aphthous stomatitis showed significantly less stimulation of DNA synthesis than comparable normal controls when exposed to heat-killed Streptococcal 2A, organisms which have been implicated in the disease. Human pathogenic strains of group A streptococci which have been implicated in rheumatic heart disease stimulated significantly less in vitro proliferation of lymphocytes from patients with rheumatic heart disease than of those from a comparable group of normal controls. This hypo-responsiveness persisted when the patients' lymphocytes were cultured in normal human serum. The chronically ill Behçet's patients' lymphocytes did not differ significantly from normal. These observations indicate a deficiency of the cellular response of certain patients to antigens from organisms thought to be aetiologically related to their disease.
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