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  • Title: Spironolactone diuresis in patients with cirrhosis and ascites.
    Author: Eggert RC.
    Journal: Br Med J; 1970 Nov 14; 4(5732):401-3. PubMed ID: 5481518.
    Abstract:
    Increased aldosterone levels with consequent or diuretic-potentiated electrolyte abnormalities are an important consideration when patients with cirrhosis and ascites undergo diuresis. A simple clinical method using the urinary Na/K ratio as a guide to spironolactone dosage is outlined. Patients with a ratio greater than 1 responded well to 100 mg. of spironolactone a day; those when it was one or less responded well to 200 to 1,000 mg. a day.Administration of spironolactone alone (11 patients) or as the main diuretic (three patients) was a safe and effective means of inducing sustained uncomplicated diuresis in all these patients.
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