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  • Title: Cyclophosphamide therapy of idiopathic nephrosis.
    Author: Grushkin CM, Fine RN, Heuser E, Lieberman E.
    Journal: Calif Med; 1970 Dec; 113(6):1-5. PubMed ID: 5486515.
    Abstract:
    Thirty-three children with steroid-dependent or steroid-resistant idiopathic nephrosis were treated with a combination of cyclophosphamide and prednisone. Remission occurred in all 23 steroid-dependent patients and, at last report, 12 had gone without any medication for periods of from two months to 21 months without relapse. Remission occurred in five of ten steroid-resistant patients. The renal biopsy findings in these patients demonstrate a correlation between the "minimal change" lesion and a positive response to cyclophosphamide.
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