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  • Title: Haem a, cytochrome c and total protein turnover in mitochondria from rat heart and liver.
    Author: Aschenbrenner B, Druyan R, Albin R, Rabinowitz M.
    Journal: Biochem J; 1970 Sep; 119(2):157-60. PubMed ID: 5488910.
    Abstract:
    Haem a and cytochrome c were isotopically labelled in mitochondria from rat heart and liver after injection of delta-amino[2,3-(3)H(2)]laevulate, a specific haem precursor. [guanido-(14)C]Arginine or l-[4,5-(3)H(2)]leucine were used to label mitochondrial proteins. Half-lives were measured from biological decay in vivo and were similar (5.5-6.2 days) for haem a, cytochrome c and [(14)C]arginine-labelled proteins. Labelling of hepatic mitochondrial proteins with [(3)H(2)]leucine resulted in a prolonged apparent half-life.
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