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  • Title: The role of rubella in the etiology of supravalvular aortic stenosis.
    Author: Vince DJ.
    Journal: Can Med Assoc J; 1970 Nov 21; 103(11):1157-60. PubMed ID: 5489321.
    Abstract:
    The possibility of an etiological relationship between rubella embryopathy and sporadic forms of supravalvular aortic stenosis is considered. A case is presented of a patient with rubella embryopathy and supravalvular aortic stenosis associated with pulmonary valvular and peripheral pulmonary artery stenosis, bicuspid aortic valve, aortic valve stenosis and subendothelial myocardial fibrosis. A review of the literature revealed many clinical and pathological features common to both syndromes. The hypothesis that rubella virus produced germ-cell mutation and subsequent persistence of rubella in the zygote produced further fetal damage is presented to explain these observations.
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