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  • Title: Oxalic acid concentration in serum measured by isotopic clearance technique. Experience in hyper- and normo-oxaluric subjects.
    Author: Prenen JA, Mees EJ, Boer P, Endeman HJ, Ephraim KH.
    Journal: Proc Eur Dial Transplant Assoc; 1979; 16():566-70. PubMed ID: 549000.
    Abstract:
    In a family from which two children suffered from primary hyperoxaluria the renal clearance of (14C) oxalate was studied. The (14C) oxalate/creatinine clearance ratio ranged from 1.76-2.63 (mean: 2.03) and appeared to be independent of glomerular filtration rate (GFR). The calculated plasma oxalate concentrations in normo-oxaluric subjects ranged from 0.1-0.9 mumol/L, whereas in hyperoxaluric subjects values between 3.2-16.3 mumol/L were found. The mean biological half-life of (14C) oxalate was 2.7hr in subjects with normal renal function and increased proportionally with renal functional impairment. Recovery of (14C) oxalate ranged from 87-112% (mean: 101%). All urine (14C) activity was found in the oxalate fraction.
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