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  • Title: Microbial aromatization of steroids into equilin.
    Author: Sehgal SN, Vézina C.
    Journal: Appl Microbiol; 1970 Dec; 20(6):875-9. PubMed ID: 5492438.
    Abstract:
    This report describes the bioconversion of 19-hydroxy-androsta-4, 7-diene-3, 17-dione into equilin with Nocardia rubra. Through mutation and improvement of medium and of conditions, the bioconversion could be improved to yield 40% equilin for a substrate concentration of 1 g/liter. Aromatization of several other 19-hydroxy and 19-nor substrates of the androstene series is reported, and the influence of various substitutions of the substrate molecule on aromatization is discussed.
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