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  • Title: Effect of low dose secretin and caerulein on pure pancreatic bicarbonate secretion and plasma secretin in man.
    Author: Greenberg GR, Domschke S, Domschke W, Rösch W, Bloom SR.
    Journal: Acta Hepatogastroenterol (Stuttg); 1979 Dec; 26(6):478-81. PubMed ID: 549430.
    Abstract:
    In six healthy volunteers pure pancreatic juice was obtained by endoscopic cannulation of the main pancreatic duct. Following a 20-min basal period, secretin (0.03 CU/kg, h) was intravenously infused alone for 20 min and then with caerulein 15 ng/kg, h for further 20 min. From a basal level of 28 +/- 13 mu mol/5 min, secretin by itself significantly increased pancreatic bicarbonate to 182 +/- 24 mu mol/5 min. A further significant two-fold increase to 396 +/- 50 mu mol/5 min was observed during caerulein. The increment in plasma secretin of 2.1 +/- 0.3 pmol/l is comparable to the rise that may be observed post-prandially. It is concluded that secretin in combination with cholecystokinin may indeed play a physiological role in the regulation of duodenal pH.
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