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  • Title: [Fibro-cystic mastosis and cancer (206 cases of mastosis in possible relation with 12 cases of cancer)].
    Author: Chardot C, Varroy A, Parache RM.
    Journal: Bull Cancer; 1970; 57(2):251-68. PubMed ID: 5505161.
    Abstract:
    From among 914 records of breast pathology, 206 cases of fibrocystic disease of the breast were extracted. They represented either as several cysts, a pseudo-tumor, or a blood-stained discharge, and those which presented histologically without objective clinical signs were discarded. Thus defined, the disease represents 1/3 of benign mammary disorders. In 88.7% of the cases, the women were between the ages of 35-55. The objective clinical signs regressed with menopause. The average weight of the women affected was 4.2 kgs less than that of the comparable population. Antecedent parity and lactation were a little less than would be expected. There is an abnormally high frequency of familial cancer of the breast. The left side and the upper outer quadrants are the most frequently attacked. Among these 206 women followed up for at least 4 years, there were 12 cancers found, possibly related to mastitis. Among them, 6 cases were among those followed up for the minimum period of observation. In comparison with 2 comparable French populations of the same age, calculations showed an increased frequency of the incidence of cancer by a factor of 7 1/2 times. Calculations have been made to determine the significance of this observation. 6 of 10 tumors examined were of the intraduct type. The authors illustrate transitions between hyperplasia and unequivocal cancer. They conclude that women subject to cystic hyperplasia of the breast with multiple clinical manifestations should be subject to regular follow-up, the precise nature of which remains to be defined. (author's)
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