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  • Title: Protective effects of a novel thromboxane analog in lethal traumatic shock.
    Author: Lefer AM, Araki H, Smith JB, Nicolaou KC, Magolda RL.
    Journal: Prostaglandins Med; 1979 Sep; 3(3):139-46. PubMed ID: 552102.
    Abstract:
    Pinane thromboxane A2 (PTA2) an analog of thromboxane A2 that inhibits the formation of thromboxanes as well as antagonizes their biological actions, at an infusion rate of 1.0 mumole . kg-1 . h-1, prolonged survival in traumatic shock in rats. PTA2 also prevented the accumulation of thromboxane B2, the lysosomal protease, cathepsin D, and the cardiotoxic peptide MDF in the circulating blood.
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