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  • Title: Control of carnitine-related metabolism during myocardial ischemia.
    Author: Shug AL.
    Journal: Tex Rep Biol Med; 1979; 39():409-28. PubMed ID: 553322.
    Abstract:
    Induction of ischemia in the open-chest dog or isolated rat heart caused a series of critical changes in carnitine-related metabolism. As a result of these metabolic changes, the LCACA/carnitine ratio rapidly increased which, in turn, may have reduced the activity of mitochondrial ANT and a number of other enzyme systems necessary for normal heart function. Carnitine administration apparently reversed these carnitine-linked metabolic changes and protected the ischemic myocardium. Possible mechanisms for the protective action of carnitine were discussed.
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