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  • Title: Irreversible effects on visible light on the retina: role of vitamin A.
    Author: Noell WK, Albrecht R.
    Journal: Science; 1971 Apr 02; 172(3978):76-9. PubMed ID: 5546288.
    Abstract:
    Diffuse retinal irradiation by visible light produces in the rat the death of visual cells and pigment epithelium. Typically, cage illumination of 1500 lux from fluorescent light through a green filter leads to severe damage when continued for 40 hours. Vitamin A deficiency protects against this damage but experiments show that retinol released by light from rhodopsin is probably not the toxic agent. Protection against light damage depends on a long-range state of cell adaptation to light itself. The normal diurnal cycle of light and dark seems to be the essential factor in controlling visual cell viability and susceptibility.
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