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  • Title: Activity of delta8- and delta9-tetrahydrocannabinol and related compounds in the mouse.
    Author: Christensen HD, Freudenthal RI, Gidley JT, Rosenfeld R, Boegli G, Testino L, Brine DR, Pitt CG, Wall ME.
    Journal: Science; 1971 Apr 09; 172(3979):165-7. PubMed ID: 5547729.
    Abstract:
    The 11-hydroxy metabolites of Delta(8).- and Delta(9)-tetrahydrocannabinol are more active than the parent compounds when administered to mice by either the intravenous or intracerebral route. Both Delta(8)- and Delta(9)-tetrahydrocannabinol are rapidly and extensively metabolized by the liver and not by the brain. The hypothesis that the 11-hydroxy metabolites may be the active form of tetrahydrocannabinol is discussed
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