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  • Title: The effect of light chloralose and pentobarbitone anaesthesia on the acid-base state and oxygenation of arterial blood in dogs.
    Author: Ledsome JR, Linden RJ, Norman J.
    Journal: J Physiol; 1971 Feb; 212(3):611-27. PubMed ID: 5557063.
    Abstract:
    1. The effects of light anaesthesia of approximately 8 hr duration using either pentobarbitone or chloralose on the acid-base balance and oxygenation of arterial blood were determined in dogs breathing spontaneously.2. With pentobarbitone anaesthesia there was a slight initial respiratory acidaemia.3. With chloralose there was a non-respiratory acidaemia which was probably the result of using an unbuffered solvent.4. Changes in the acid-base balance and the oxygen concentration of the arterial blood over the course of each experiment were minimal.5. In one animal a pH of 7.07 was recorded; in others the oxygen tension on occasion was between 50 and 60 mm Hg. The value of monitoring the acid-base state and the oxygenation of blood in experimental preparations is discussed.
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