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  • Title: Therapeutic abortion and induction of labour by the intravaginal administration of prostaglandins E 2 and F 2- .
    Author: Karim SM, Sharma SD.
    Journal: J Obstet Gynaecol Br Commonw; 1971 Apr; 78(4):294-300. PubMed ID: 5558312.
    Abstract:
    This paper describes the use of prostaglandins E2 and F2 alpha (PGE2, PGF2alpha) administered vaginally for 1st and 2nd trimester abortion and for labor induction at term. 45 patients (21 were nulliparous) aged 14-42 years with periods of amneorrhea ranging from 7-23 weeks were given PGF2alpha and PGE2 vaginal tablets to be inserted every 2-1/2 hours until abortion occurred. 30 patients received PGE2 (20 mg) and 15 received PGF2alpha (50 mg). All 45 women aborted, with 40 having complete abortion and 5 necessitating evacuation of retained products of conception. Average induction-abortion interval was 13 hours 15 minutes. Time to onset of regular rhythmic uterine activity was between 3-7 minutes. Vomiting occurred in 6 women (3 with PGF2alpha and 3 with PGE2) and diarrhea in 1 (PGF2alpha); maternal pulse and blood pressure were not affected, and blood loss was minimal. Average duration of hospital stay was 24 hours. No apparent complications were reported. Induction of labor at term using the vaginal tablets was attempted in 10 women with intact membranes. 5 women received PGE2 (2 mg) tablets and another 5 received PGF2alpha tablets every 2 hours until labor was established as judged by a cervical dilatation of 5-6 cm and adequate uterine contractions every 2-3 minutes. All the infants were born alive. There were no reported side effects. The vaginal administration of PGs for pregnancy termination is more acceptable and more practical than continuous intravenous infusion.
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