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  • Title: 5'-Terminal structure and mRNA stability.
    Author: Furuichi Y, LaFiandra A, Shatkin AJ.
    Journal: Nature; 1977 Mar 17; 266(5599):235-9. PubMed ID: 557727.
    Abstract:
    Reovirus mRNAs with 5'terminal m7GpppGm or GpppG are more stable than mRNA containing unblocked ppG 5'-ends when injected into Xenopus laevis oocytes or incubated in cell-free protein synthesising extracts of wheat germ and mouse L cells. The greater stability of mRNA with blocked 5' termini is not dependent upon translation but seems to result from protection against 5'-exonucleolytic degradation.
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