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  • Title: Pre- and post-synaptic actions of apomorphine: differentiation by rotatory effects in normal rats.
    Author: Glick SD, Jerussi TP, Cox RD, Fleisher LN.
    Journal: Arch Int Pharmacodyn Ther; 1977 Feb; 225(2):303-7. PubMed ID: 557962.
    Abstract:
    Normal rats were tested for rotation (circling behavior) following d-amphetamine (1.0 mg/kg) and, a week later, following apomorphine (10.0 mg/kg). In most rats, d-amphetamine and apomorphine elicited rotation in opposite directions whereas, in some rats, the two drugs elicited rotation in the same direction. Subsequently, alpha-methyl-p-tyrosine was found to antagonize the rotatory effect of apomorphine in the latter but not in the former rats. The results suggest that apomorphine has both pre- and post-synaptic actions and that relative sensitivity to these actions varies among rats.
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