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  • Title: The mechanism of excitation by acetylcholine in the cerebral cortex.
    Author: Krnjević K, Pumain R, Renaud L.
    Journal: J Physiol; 1971 May; 215(1):247-68. PubMed ID: 5579661.
    Abstract:
    1. The muscarinic depolarizing action of ACh on cortical neurones is associated with an increase in membrane resistance (mean DeltaV/DeltaR = 3.16 mV/MOmega).2. ACh also promotes repetitive firing by slowing repolarization after spikes.3. The depolarizing effect has a mean reversal level of -86.7 mV (with mean resting potential -56 mV).4. It is concluded that as a muscarinic excitatory agent, ACh probably acts by reducing the resting K(+) conductance of cortical neurones, and also the delayed K(+) current of the action potential.5. These results are discussed in relation to the possible role of ACh in cortical function.
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