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  • Title: Development of a radioimmunoassay for theophylline. Application to studies in premature infants.
    Author: Neese AL, Soyka LF.
    Journal: Clin Pharmacol Ther; 1977 May; 21(5):633-41. PubMed ID: 558079.
    Abstract:
    The use of theophylline in premature infants has necessitated the development of an assay applicable to samples under 0.1 ml. To accomplish this we have developed a radioimmunoassay for theophylline. The antiserum to theophylline has been characterized and found to be highly specific for theophylline and sensitive to 2 ng. The affinity of our antibody and the titer developed in the goat allowed the assay to be performed routinely with the use of a plasma sample size of only 2 to 5 micronl. Theophylline levels of 6 to 20 microng/ml were found 2 hr after maintenance doses of aminophylline, 4 mg/kg per rectum in 12 premature infants. Terminal serum half-lives ranged from 12 to 54 hr.
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