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  • Title: [Conjugation components in alpha-adrenergic reactions in smooth muscles].
    Author: Abramets II.
    Journal: Farmakol Toksikol; 1977; 40(2):153-7. PubMed ID: 558112.
    Abstract:
    Changes in the electric and mechanical activity conditioned by norepinephrine in the deferent duct, musculus rectococcygeus, aortic band and the portal vein in rats, as well as influence exerted on these changes by the replacement of Na+ ions with NH4+ ones, by the action of novocain (1-10(-3) g/ml), strophanthin (1-10(-5) g/ml), excess (25 mM) and deficiency (0.25 mM) of Ca2+ ions and by that of manganese chloride (2 mM) and lanthanum (1 mM) were analyzed. As evidenced, the basic mode of conjugation in alpha-adrenergic reactions is an intensified supply of Ca2+ ions to the cells, unattended by any changes in the degree of the membrane potential at rest. Depolarization and quickened generation of action potentials occur in musculus rectococcygeus and in the portal vein, in the lastly named case -- under the effect of high norephrine concentrations (10(-6)-10(-5) g/ml).
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