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  • Title: Kayser-Fleischer-like rings in patients without Wilson's disease.
    Author: Frommer D, Morris J, Sherlock S, Abrams J, Newman S.
    Journal: Gastroenterology; 1977 Jun; 72(6):1331-5. PubMed ID: 558126.
    Abstract:
    Three patients, one with cryptogenic cirrhosis, one with active chronic hepatitis and one with neonatal hepatitis, were found to have corneal pigmentation rings indistinguishable from early Kayser-Fleischer rings on slit lamp examination. They did not have the clinical features of Wilson's disease and their serum copper and ceruloplasmin concentrations were normal. Urinary copper excretion rates and hepatic concentrations were only slightly raised but were below the range found in symptomatic Wilson's disease. It is concluded that the Kayser-Fleischer ring would no longer be considered as pathognomonic of Wilson's disease.
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