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  • Title: [Biotransformation of rifampicin in pulmonary tuberculosis patients].
    Author: Ioffe RA.
    Journal: Antibiotiki; 1977; 22(2):177-80. PubMed ID: 558736.
    Abstract:
    Biotransformation of rifampicin in 39 tuberculosis patients treated with the drug was studied. The studies showed that biotransformation of rifampicin was most intensive during the first 3--6 hours after its use, which was confirmed by excretion of maximum amounts of rifampicin and its metabolites with the urine. 2--4 weeks after the beginning of the treatment with rifampicin excretion of its metabolism products decreased. When rifampicin was used simultaneously in a single dose with tubazid excretion of rifampicin transformation product and desacetylation of the antibiotic slowed down.
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