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  • Title: Invasion of malignant cells into 51Cr-labeled host tissues in organotypical culture.
    Author: Mareel M, de BRUYNE G, de Ridder L.
    Journal: Oncology; 1977; 34(1):6-9. PubMed ID: 559277.
    Abstract:
    We have attempted to quantitate malignant invasion in vitro. Therefore we adapted the 51Cr-release cytotoxicity test to organotypical culture systems, that proved useful for morphological analysis of invasion. We counted 51Cr-release from labeled fragments of embryonic chick heart and mesonephros, cultured either on semi-solid or in fluid medium, during their invasion by HeLa cells. Although demonstrated morphologically, malignant invasion did not bring about significant changes of 51Cr-release as compared to control cultures without HeLa cells. The failure of the 51Cr-release test in our experimental device might shed some light on the mechanisms of malignant invasion.
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