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  • Title: [Primary and secondary immune response in animals following spontaneous loss of tolerance].
    Author: Kazarian KA, Tat'ian MV, Kirakosian SD, Fontalin LN.
    Journal: Biull Eksp Biol Med; 1977 Jun; 83(6):716-8. PubMed ID: 560228.
    Abstract:
    Mice subjected to tolerogenic treatment by sheep red blood cells (SRBC) and cyclophosphamide were immunized at various intervals (from 1 to 8 weeks after treatment) either by a single injection of 5 X 10(8) SRBC or by a double-injection of 1 X 10(6) SRBC. In control mice both immunization methods proved to be equally successful. In the experimental animals the immunological memory formation and/or its realization was destroyed to a greater extent and was restored more slowly than the capacity to the primary response.
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