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  • Title: [The protective effect of hydroxyethylstarch (HES) in the cryoconservation of bone marrow of the mouse and of man (author's transl)].
    Author: Schaefer UW, Beyer JH.
    Journal: Anaesthesist; 1975 Dec; 24(12):505-6. PubMed ID: 56144.
    Abstract:
    The cryoprotective effect of hydroxyethylstarch has been tested in mice and in man using the spleen colony technique (CFU-S test) or the agar colony technique (CFU-C test) as viability assays for the haemopoietic stem cell. In mice we found a mean CFU-S recovery of 88.7%+/-3.9% when a rapid, and 77.8%+/-3.2% when a slow, stepwise dilution method was applied to remove the protective medium (17.5-20% hydroxyethylstarch+20% calf serum) after thawing. In man the rapid dilution after thawing gave a mean CFU-C recovery of 80% but a wide scatter.
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