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  • Title: Enkephalin: radioimmunoassay and radioreceptor assay in morphine dependent rats.
    Author: Childers SR, Simantov R, Snyder SH.
    Journal: Eur J Pharmacol; 1977 Dec 01; 46(3):289-93. PubMed ID: 563332.
    Abstract:
    A sensitive and specific radioimmunoassay for enkephalins is described which discriminates between leucineenkephalin and methionine-enkephalin. Total opioid peptide activity was assayed by the ability of brain extracts to compete for opiate receptor binding. In rats treated with morphine and/or naloxone, opiates were separated from opioid peptides by Dowex AG-50W column chromatography prior to radioreceptor assay. Chronic administration of morphine failed to alter immunoreactive enkephalin levels or total opioid activity in radioreceptor assays.
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