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  • Title: A kinetic study of antibody producing cells in the spleen of mice immunized intravenously with sheep erythrocytes.
    Author: Biozzi G, Stiffel C, Mouton D, Bouthillier Y, Decreusefond C.
    Journal: Immunology; 1968 Jan; 14(1):7-20. PubMed ID: 5635755.
    Abstract:
    The number of antibody producing cells, i.e. rosette forming cells (RFC) has been studied in the spleen of mice injected intravenously with a full immunizing dose of sheep RBC. The spleen of a non-immunized mouse contains a background of about 70,000 RFC (normal RFC), which do not appear to be the `target cells' for antigens of sheep RBC. Our findings suggest that the spleen of a mouse contains about 4000 `target cells' which initiate the immune response to sheep RBC. In the primary response, the rise of RFC is exponential for about 96 hours with a doubling time of 13 hours involving seven to eight consecutive doubling periods. The peak value of RFC is 1·6 × 106 per spleen. In the secondary response, the doubling time of RFC is 6–7 hours. The exponential rise lasts 72 hours and includes nine to eleven doubling periods leading to a peak of 3·5 × 106 RFC/spleen. Adjuvant in the primary response leaves the doubling time of RFC unaltered but prolongs the exponential rise until the 120th hour leading to a peak of 6·3 × 106 RFC/spleen after ten doubling periods. The effects of priming and adjuvant are not fully additive.
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