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  • Title: [Suppression of the damaging effect of amphotericin B on dog kidney lysosomes by amigluracyl].
    Author: Kravchenko LS, Oksman AIa, Tereshin IM.
    Journal: Antibiotiki; 1977 Nov; 22(11):1018-22. PubMed ID: 563700.
    Abstract:
    The effect of amphotericin B and its combination with amigluracyl on the dog kidney lyzosomes was studied in vitro. It was found that on incubation of the lyzosomes with the antibiotic in a concentration of 1 gamma/ml the latter stimulated liberation of proteases from them. At the same time, when the lyzosomes were exposed to amphotericin B in combination with amigluracyl, a significant decrease in the rise of the proteolytic activity in the incubation medium due to the antibiotic was observed. It was found that the combined use of amphotericin B with amigluracyl resulted in an intensive inhibition of the enzyme activity; The data are indicative of the fact that amigluracyl decreases the damaging effect of the antibiotic on the dog kidney lyzosomes.
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