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  • Title: Androgen aromatization by luteinized bovine granulosa cells in tissue culture.
    Author: Henderson KM, Swanston IA.
    Journal: J Reprod Fertil; 1978 Jan; 52(1):131-4. PubMed ID: 563910.
    Abstract:
    Luteinized bovine granulosa cells in tissue culture contained an active 19-hydroxylase aromatase enzyme system which converted exogenous androstenedione and testosterone to oestradiol-17beta; no oestrone was detected. In the absence of exogenous androgens, the cells failed to synthesize oestrogens due to a limited capacity to synthesize androgen precursor. Theca-lutein cells, present in those CL which synthesize oestrogens, may provide androgen precursor for aromatization by the granulosa-lutein cells.
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